Volume 26, Number 10 (Monthly_Jan 2016)                   J Urmia Univ Med Sci 2016, 26(10): 828-835 | Back to browse issues page


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Karimi M, Dalimi , A, Jameie F, Dalimi A, Ghafarifar F. HEALING EFFECT OF INDUCTION OF DIRECT ELECTRIC CURRENTS PLUS SELENIUM AND SILVER NANOPARTICLE ON SKIN LESIONS CAUSED BY LEISHMANIAL MAJOR IN BALB/C MICE. J Urmia Univ Med Sci. 2016; 26 (10) :828-835
URL: http://umj.umsu.ac.ir/article-1-3188-en.html

Professor, Parasitology Department, Medical Sciences Faculty, Tarbiat Modares University, Tehran, Iran , dalimi_a@modares.ac.ir
Abstract:   (2785 Views)

Abstract

Background & Aims: Various Leishmania species can cause human infection with a spectrum of clinical manifestations. The current treatments are unsatisfactory; and in absence of a vaccine there is an urgent need for effective drugs to replace those currently in use. In the present study, the effect of direct current electricity in combination with selenium and silver nanoparticles on the healing of leishmanial lesions has been investigated.

Materials & Methods: In this experimental study, 24 Balb/c mice were divided into four groups and infected experimentally with L.major. Then silver nanoparticles with a concentration of 250 mg/kg and selenium nanoparticle with a concentration of 125 mg/kg were injected inter-lesion, and simultaneously 0.5 mA DC induction was applied directly into the wound. Finally, the lesion size and mice body weight changes were measured during five weeks.

Results: The lesions were found to be smaller in the group treated with DC and silver nanoparticles than the group treated with DC and selenium nanoparticles (P < 0.05). Two treated groups showed significant differences with both negative control group and the group treated with Glucantime (P < 0.05).

Conclusion: The results showed that selenium and silver nanoparticles with direct current electricity promotes wound healing in mice.

SOURCE: URMIA MED J 2016: 26(10): 835 ISSN: 1027-3727

Full-Text [PDF 469 kb]   (458 Downloads)    
Type of Study: Research | Subject: انگل و قارچ شناسی
Received: 2016/01/14 | Accepted: 2016/01/14 | Published: 2016/01/14

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