Volume 26, Issue 9 (Monthly_Dec 2015)                   J Urmia Univ Med Sci 2015, 26(9): 743-753 | Back to browse issues page

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Ghazizadeh T, Ghorbani Haghjo A, Argani H, Raeisi S, Safa J, Aliasgari J et al . EVALUATION OF ANTIOXIDANT ACTIVITY OF KLOTHO IN HEMODIALYSIS PATIENTS AND RENAL TRANSPLANT RECIPIENTS. J Urmia Univ Med Sci. 2015; 26 (9) :743-753
URL: http://umj.umsu.ac.ir/article-1-3134-en.html
Professor in Clinical Biochemistry, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran , ghorbaniamir@hotmail.com
Abstract:   (3393 Views)

Received: 16 Aug , 2015 Accepted: 22 Oct , 2015

Abstract

Background & Aims: The aim of this study was to evaluate serum levels of antioxidant property Klotho by examining 8-hydroxy-2'- deoxyguanosine (8-OHdG), as  a marker of oxidative damage in nucleic acids in patients with hemodialysis and kidney transplantation.

Materials & Methods: Serum samples from 45 patients undergoing hemodialysis and 45 patients with stable renal transplant recipients were collected. Klotho levels, 8OHdG, iPTH and vitamin D (25 (OH) D) were measured using standard methods.

Results: Klotho level in hemodialysis patients was significantly higher (p&le0.001). Considering the serum levels (8-OHdG), there was no significant difference between the two groups (p=0.242). Serum parathyroid hormone levels in hemodialysis patients was significantly higher while the correlation between serum levels of iPTH and Klotho in none of the two groups were observed.

Conclusion: It seems that high levels of Klotho in hemodialysis patients is a secondary response to high levels of parathyroid hormone, or just due to the use of immunosuppressive drugs in renal transplant recipients.

SOURCE: URMIA MED J 2015: 26(9): 753 ISSN: 1027-3727

Full-Text [PDF 551 kb]   (850 Downloads)    
Type of Study: Research | Subject: بیوشیمی

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