Volume 26, Number 8 (Monthly_Oct 2015)                   J Urmia Univ Med Sci 2015, 26(8): 634-642 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Darabi N, Yousefi S, Motazakker M, Khalkhali H R. ANTIBIOTIC SUSCEPTIBILITY PATTERN AMONG CLINICAL STRAINS OF KLEBSIELLA PNEUMONIA ISOLATED FROM URMIA UNIVERSITY TEACHING HOSPITALS, AND DETERMINATION OF MIC AGAINST IMIPENEM IN RESISTANT ISOLATES. J Urmia Univ Med Sci. 2015; 26 (8) :634-642
URL: http://umj.umsu.ac.ir/article-1-3091-en.html

Assistant Professor, Microbiology Department Microbiology Department, Cellular and Molecular Research Center, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran , yousefi_s@umsu.ac.ir
Abstract:   (3034 Views)

Received: 6 Jul, 2015 Accepted: 16 Sep, 2015

Abstract

Background & Aims: In recent years, the emergence of multi drug resistant Klebsiella pneumonia is responsible for many therapeutic problems all over the world. Nowadays carbapenems are often considered as the final options for antibiotic treatment of infections caused by most Gram-negative bacilli. The aim of this study was to determine antibiotic resistance pattern (with focus on carbapenems) of K. pneumoniaeisolates from clinical specimens of in-patients and out-patients admitted to Urmia University of Medical Sciences teaching hospitals.

Materials & Methods: In this descriptive-analytical study, 182 isolates of K. pneumonia were investigated. All bacterial isolates were identified as K. pneumoniae by using standard microbiological tests. Antimicrobial susceptibility testing of confirmed isolates was carried out by disk diffusion method proposed by (Kirby-Bauer) against 12 different antibiotics. The minimum inhibitory concentration (MIC) of imipenem for each isolate was determined using E-test method.

Results: Accordingly, 43 isolates (23.6%) were resistant to imipenem, and 45 isolates (24.7%) belonged to multiple drug resistant (MDR) phenotypes. These isolates demonstrated high resistance to imipenem and meropenem. The MIC of imipenem for resistant isolates was &ge32 µg/ml.

Conclusion: Considering the high prevalence of resistance to imipenem, especially in Klebsiella pneumonia isolates from patients admitted to ICU wards in the present study and various reports from other countries, precaution should be taken in the administration of these drugs. Also determination of bacterial susceptibility prior to prescription of antimicrobial agents is crucial for proper treatment and preventing the dissemination of antimicrobial resistance.

SOURCE: URMIA MED J 2015: 26(8): 642 ISSN: 1027-3727

Full-Text [PDF 372 kb]   (755 Downloads)    
Type of Study: Research | Subject: میکروبیولوژی
Received: 2015/11/18 | Accepted: 2015/11/18 | Published: 2015/11/18

Add your comments about this article : Your username or email:
Write the security code in the box

Send email to the article author


© 2015 All Rights Reserved | URMIA MEDICAL JOURNAL

Designed & Developed by : Yektaweb