Volume 26, Number 7 (Monthly-Sep 2015) | J Urmia Univ Med Sci 2015, 26(7): 594-601 | Back to browse issues page


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Hatami K, Yousofvand N, Sayadi F. EFFECT OF DILL (ANETHUM GRAVEOLENS L) ETHANOL EXTRACT ON PAIN AND MORPHINE-INDUCED ANALGESIA IN MALE MICE. J Urmia Univ Med Sci. 2015; 26 (7) :594-601
URL: http://umj.umsu.ac.ir/article-1-3031-en.html

Assistant Professor, Department of Biology Department of Biology, Faculty of Science, Razi University, Kermanshah , Yousofnam@yahoo.com
Abstract:   (2178 Views)

 

Background & Aims: Due to the side effects of chemical drugs and their expensive prices, nowadays medicinal plants are of great interest, and dill is one of these plants. The aim of the present study was evaluating analgesic effect of dill ethanol extract in male mice by using formalin test in the presence and absence of intravenous morphine.

Materials & Methods: In this study, 28 mice were used and divided into 4 groups of control, morphine (positive control), dill, and dill+ morphine. Ethanol extract of dill, 500 milligrams per liter in drinking water for 30 days was given to the animals. In positive control group, 10mg/kg of morphine was injected with a single dose subcutaneously. Pain scores obtained using formalin test with injection 0.02 ml of formalin 5% to the fourth finger of the animals’ right hand.

Results: The results of this study showed that dill ethanol extract by oral administration method decreased pain scores in the acute and chronic phases of formalin-induced pain. Concurrent using of ethanol extract of dill and morphine had dramatic analgesic effect.

Conclusion: The results of this study confirm that compounds present in dill have analgesic effects and also increase the analgesic effects of morphine.

 

SOURCE: URMIA MED J 2015: 26(7): 601 ISSN: 1027-3727

Full-Text [PDF 472 kb]   (833 Downloads)    
Type of Study: Research | Subject: بیوشیمی
Received: 2015/10/14 | Accepted: 2015/10/14 | Published: 2015/10/14

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