Volume 26, Number 7 (Monthly-Sep 2015)                   J Urmia Univ Med Sci 2015, 26(7): 542-549 | Back to browse issues page


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Kazemi A, Nowrozi H. ORAL VITAMIN E EFFECT ON ASPIRIN -INDUCED GASTRIC ULCERS BY ORAL AND PARENTERAL ADMINISTRATIONS IN RAT. J Urmia Univ Med Sci. 2015; 26 (7) :542-549
URL: http://umj.umsu.ac.ir/article-1-3026-en.html

Assistant Professor of Nursing and Midwifery Varamin- Pishva Branch, Islamic Azad University, Varamin, Iran , alikazemi611@gmail.com
Abstract:   (2965 Views)
Background &Aims: Gastric ulcers are common worldwide that occur due to different agents such as stress, cigarettes, non-steroid anti inflammatory drugs (NSAIDs) administration, and ethanol. NSAIDs are responsible for 15- 25 % all gastric ulcers. This study was done to evaluate the effects of oral vitamin E on oral and intra peritoneal (I.P) aspirin induced-gastric ulcers in rats. Materials & Methods: This experimental (interventional) study was done on 30 rats weighing 200±20 gr which randomly were divided into 5 groups including the control group, group receiving 200 mg/kg oral aspirin, group receiving 200 mg/kg aspirin as I.P, group receiving 100 mg/kg vitamin E pre oral aspirin administration, and group receiving 100 mg/kg vitamin E pre I.P administration of aspirin groups. Ulcers were evaluated by J. Score method (reported as J.Score±S.E.M.t student), and ANOVA was used for data analysis. Results: J. Score of IP administration of aspirin was 18.83±0.5 and then J. Score of oral administration of aspirin was 16.1±0.6 , J. score of vitamin E ± I.P administration of aspirin was 8.6 ± 0.3 and finally J. score of vitamin E±oral administration of aspirin was 7.3±0.4. Significant decrease was considered in ulcers in groups in which oral vitamin E administrated pre aspirin administration (P< 0.05). Conclusion: Vitamin E decreased aspirin induced gastric ulcers via antioxidant effects. SOURCE: URMIA MED J 2015: 26(7): 549 ISSN: 1027-3727
Full-Text [PDF 338 kb]   (609 Downloads)    
Type of Study: Research | Subject: گوارش و کبد
Received: 2015/10/14 | Accepted: 2015/10/14 | Published: 2015/10/14

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