Background & Aims: ABCA1 as a member of the ABC transporters family plays a crucial role in RCT, HDL-C formation andultimatly CAD prevention. The purpose of this study was to investigate ABCA1 expression in lymphocytes, plasma apolipoprotein A-I and lipid profiles in response to eight weeks interval combined endurance training (ICET) among overweight and obese boy adolescents.

Materials & Methods: This study was conducted on 28 healthy overweight and obese male adolescents (17.1 ± 1.08 yr, 89.91 ± 9.98 kg and 28.32 ± 2.55 kg / m²) who volunteered and were randomly assigned into training (n = 13) and control (n = 15) groups. Exercise protocol was ICET (8WK, 4 d/wk, 70 min/d). Cell hemolysis and sensitive Elisa method was used for Lymphocyte ABAC1 measurement. The Student's t-test and SPSS₁₆ were employed for data analysis.

Results: The results showed that in post-exercise the amounts of ABCA1 and VO₂ max significantly increased and TC,TG, LDL-c/HDL-c, TC/HDL-c, and PBF, WC and BMI significantly decreased (p>0.05). Changes in other variables such as ApoA-I, HDL-c, LDL-c, and body weight were not significant (p<0.05).

Conclusion: It seems that ICET can have positive effects on ABCA1 (as important factor RCT) and some lipid and physiological indicators and ultimately in prevention of arteriosclerosis in overweight and obesity of adolescents.

SOURCE: URMIA MED J 2015: 26(3): 236 ISSN: 1027-3727