Volume 25, Number 8 (Monthly oct 2014)                   J Urmia Univ Med Sci 2014, 25(8): 693-705 | Back to browse issues page


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Tabesh M, Azadbakht L, Faghihimani E, Tabesh M, Esmaillzadeh , A. EFFECTS OF CALCIUM-VITAMIN D CO-SUPPLEMENTATION ON METABOLIC PROFILES IN VITAMIN D INSUFFICIENT PEOPLE WITH TYPE 2 DIABETES: A RANDOMIZED CONTROLLED CLINICAL TRIAL. J Urmia Univ Med Sci. 2014; 25 (8) :693-705
URL: http://umj.umsu.ac.ir/article-1-2444-en.html

Associate Professor Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan , esmaillzadeh@hlth.mui.ac.ir
Abstract:   (4029 Views)

 

Background & Aims: To the best of our knowledge, no study has examined the effects of vitamin D-calcium co-supplementation on glycemic status and lipid profiles of vitamin D insufficient people with diabetes. This study was performed to assess the effects of vitamin D and calcium supplementation on metabolic profiles of vitamin D insufficient persons with type 2 diabetes.

Materials & Methods: In a randomized placebo controlled clinical trial, a total of 118 persons with vitamin D insufficiency and type 2 diabetes were enrolled. Subjects were randomly assigned into four groups receiving: 1) 50000 IU/wk vitamin D+calcium placebo 2) 1000 mg/d calcium +vitamin D placebo 3) 50000 IU/wk vitamin D+1000 mg/d calcium 4) vitamin D placebo +calcium placebo for 8 weeks. All participants provided three days of dietary records and three days of physical activity records throughout the intervention. Blood samples were taken to quantify metabolic profile sat study baseline and after 8 weeks of intervention.

Results: Calcium-vitamin D co-supplementation resulted in reduced serum insulin (-14.8±3.9 pmol/L, P=0.01), HbA1c (-0.70±0.19%, P=0.02), HOMA-IR(-0.46±0.20, P=0.001), LDL-(-10.3±0.1 mmol/L, P=0.04) and total/HDL-cholesterol levels (-0.91±0.16, P=0.03) compared with other groups. We found a significant increase in QUICKI index (0.02±0.01, P=0.004), HOMA-B (11.8±12.17, P=0.001) and HDL-cholesterol (0.46±0.05 mmol/L, P=0.03) levels in calcium-vitamin D group compared with others. Vitamin D supplementation led to a significant improvement in all biomarkers of glycemic status, except for fasting plasma glucose, compared with no-vitamin D group.

Conclusion: Joint calcium-vitamin D supplementation might improve glycemic status and lipid profiles in vitamin D insufficient people with type 2 diabetes.

 

SOURCE: URMIA MED J 2014: 25(8): 705 ISSN: 1027-3727

Full-Text [PDF 624 kb]   (804 Downloads)    
Type of Study: Research | Subject: آناتومی
Received: 2014/10/26 | Accepted: 2014/10/26 | Published: 2014/10/26

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