Volume 25, Issue 1 (Monthly march 2014)                   Studies in Medical Sciences 2014, 25(1): 51-55 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Aghdashi M A, Sharifi Y, Derakhshanfar M. EVALUATION OF INFLUENZA VACCINATION EFFECTS IN DISEASE ACTIVITY AND AUTOANTIBODY GENERATION IN SYSTEMIC LUPUS ERYTHEMATOUS. Studies in Medical Sciences 2014; 25 (1) :51-55
URL: http://umj.umsu.ac.ir/article-1-2102-en.html
Microbiology Department, Faculty of Medicine, Urmia University of Medical Sciences , sh_y1347@yahoo.com
Abstract:   (9918 Views)

  

 Background & Aims: Systemic lupus erythematous (SLE) patients are susceptible to various infections due to inappropriate immune responses and using variety of immunosuppressive therapies. In this condition, influenza vaccination is an option that seems to contribute the patients. However, there is a lack of data regarding vaccination in SLE patients in Iran that prompted us to design a study to evaluate the impact of influenza vaccine in SLE patients.

 Materials & Methods: Twenty-four SLE patients were selected and underwent blood sampling for autoantibody titers before receiving influenza vaccine and rechecked 12 weeks after vaccination. All patients were monitored for any vaccination complications and SLE disease activity index (SLEDAI).

 Results: There was no significant difference in serum level of ANA (p= 0.44), Anti Ds DNA (p= 0.98), C3 (p= 0.36) and C4 (p=0.49) in patients before and 12 weeks after vaccination. Serum level of CH50 before and after vaccination was significantly different (p= 0.002).

 Conclusion: Based on this research, we didn’t observe any changes in SLEDAI or vaccination complications and considering high risk of pneumonia in SLE patients, vaccination program for this population will be better and beneficial.

 

  SOURCE: URMIA MED J 2014: 25(55): 20 ISSN: 1027-3727

Full-Text [PDF 115 kb]   (2902 Downloads)    
Type of Study: Research | Subject: آناتومی

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Studies in Medical Sciences

Designed & Developed by : Yektaweb