Volume 24, Number 6 (Monthly sep 2013)                   J Urmia Univ Med Sci 2013, 24(6): 405-413 | Back to browse issues page


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Heidari A, Akbari A, Peirouvi T. DETERMINATION OF DEXTROMETHORPHAN IN PHARMACEUTICAL FORMULATIONS AVAILABLE IN DRUG MARKET OF IRAN USING HPLC METHOD. J Urmia Univ Med Sci. 2013; 24 (6) :405-413
URL: http://umj.umsu.ac.ir/article-1-1806-en.html

Assistant Professor of Pharmacology Cellular and Molecular Research Center, Urmia University of Medical Sciences , heydari.866@gmail.com
Abstract:   (4566 Views)

  

  Background & Aims : Quality control is the most common function to test and measure material and product. Quality control of active ingredients in drug formulation is to control the quality of the products of a company and evaluate their stability. The purpose of this study was to determine the amount of dextromethorphan available in drug market of Iran.

  Materials & Methods : For this purpose different pharmaceutical formulations of dextromethorphan with different serial number preparations were purchased from the market. Based on their standard methods of extraction (USP Pharmacopeia) the active ingredient dextromethorphan was extracted and determined by using HPLC Colum. The method utilize fluorescence detector.

  Results : The results of this project on 40 commercial products were as follow: The respective forms of pharmaceutical tablets were 104-124% drops 87-92% simple syrup 91-119% and syrup mixture 109-120% of labeled.

  Conclusion : The assay results obtained from forty commercially available formulations of tablet and syrup were more than the amounts declared which agree with the tolerances indicated by the USP pharmacopeia while the assay results for drops were less than the declared values.  

  SOURCE: URMIA MED J 2013: 24(6): 413 ISSN: 1027-3727

Full-Text [PDF 165 kb]   (968 Downloads)    
Type of Study: Research | Subject: آناتومی
Received: 2013/09/3

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