Volume 23, Number 7 (3-2013)                   J Urmia Univ Med Sci 2013, 23(7): 807-817 | Back to browse issues page


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Taribiyan٭ B, Baghaiee B, Monfaredan A, Mosafery E. EXPRESSION OF ADRENERGIC RECEPTOR BETA-2 AND FMD LEVEL IN UNTRAINED MIDDLE-AGED MEN: EFFECT OF EIGHT WEEK REGULAR EXERCISE TRAINING. J Urmia Univ Med Sci. 2013; 23 (7) :807-817
URL: http://umj.umsu.ac.ir/article-1-1601-en.html

Associate Professor of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Urmia University, Urmia, Iran , ba_tartibian@gmail.com
Abstract:   (4767 Views)

  Background & Aims : This research was aimed to investigate hypertension Adrenergic Receptor B2 (ADRB2) gene expression and Flow Mediate Dilation (FMD) level in untrained middle-aged men fallowing to eight week regular exercise training.

  Materials & Methods : This study was a semi-experimental research with a repeated measures design. From 96 volunteer middle-aged men, 20 subject (age range of 45-55 years) participated in this study after signing an informed consent form. Next, subject divided in two groups of training (10 person) and control (10 person) groups and performed the eight week moderate exercise training (time: 45 minutes, speed: 50-65 maximal hear rate, slope: 0%). These factors (ADRB2 and FMD) were investigated in three times: baseline, after 4 week and after 8 week. Real time- PCR was used for evaluation of Adrenergic Receptor B2 (ADRB2) mRNA and Pulsed Doppler Velocity Signal for Flow Mediated Dilation (FMD).

  Result : ADRB2 gene expression in training group were significant increased after four and eight week exercise training (P<0.001) but this receptor expression was significant increased after four week being untrained in control group (P= 0.026), but decreased after 8 week (P=0.386). FMD level was significant increased in training group after 4 and 8 week (P=0.001), in control group, FMD were not significant changes after 4 week being untrained (P=0.35), but after 8 weeks being untrained, significantly decreased (P=0.010).

  Conclusion : Regular exercise training has increased the expression of ADRB2 and FMD level in middle-aged men, but untraining decreased this factors.

SOURCE: URMIA MED J 2012: 23(7): 831 ISSN: 1027-3727

   

Full-Text [PDF 176 kb]   (1186 Downloads)    
Type of Study: Research | Subject: آناتومی
Received: 2013/03/18 | Accepted: 2013/03/18 | Published: 2013/03/18

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