Volume 23, Number 7 (3-2013)                   J Urmia Univ Med Sci 2013, 23(7): 784-791 | Back to browse issues page


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Hajari-Taheri F, Yazdi M, Mahdavi M, Shokrgozar M, Bayat M, Abolhassani M. STUDY OF PROTECTIVE EFFECT OF LACTOBACILLUS ACIDOPHILUS AND LACTOBACILLUS CASEI IN REDUCING THE CANDIDA ALBICANS INFECTION IN BALB/C MICE. J Urmia Univ Med Sci. 2013; 23 (7) :784-791
URL: http://umj.umsu.ac.ir/article-1-1599-en.html

Professor of Immunology, Hybridoma Lab, Dept. of Immunology, Pasteur Institute of Iran, Tehran, Iran , mabolhassani@yahoo.com
Abstract:   (8153 Views)

  Received: 12 Sep, 2012 Accepted: 15 Des, 2012

  Abstract

  Background & Aims : Candida albicans is one the widespread opportunistic fungal causing disease in human. Probiotics are useful bacteria with immunomodulatory effects on different spectrum of diseases. In this study the protective effect of Lactobacillus acidophilus and Lactobacillus Casei in reducing the Candida albicans infection in BALB/c mice were investigated.

  Material & Methods : BALB/c mice were fed orally with 2.4 × 108 probiotics for a month and then were infected systemically with 2 × 10 6 Candida albicans via tail vein. Mice were again fed with probiotics for 2 weeks and then were sacrificed and the spleen cells were isolated and cultured with phytohemaglutinin. In the supernatant, the amount of IL-12, IL-4, TGF-β, and IFN-γ were measured using ELISA.

  Results : Our results showed that mice using Lactobacillus Acidophilus had increased IL-4 and IL-12 level. However, the level of TGF-β was increased significantly in all infected mice. The results also show that with the applied dosage, the probiotics are not able to increase lymphocyte proliferation or mice survival.

  Conclusion : These results showed that in mice model system with the schedule and dosage we used probiotics can be used as prophylactic but they from immunological point are not effective for treatment of Candida albicans systemic infection.

  

  SOURCE: URMIA MED J 2012: 23(7): 828 ISSN: 1027-3727

  

Full-Text [PDF 229 kb]   (1033 Downloads)    
Type of Study: Research | Subject: آناتومی
Received: 2013/03/18 | Accepted: 2013/03/18 | Published: 2013/03/18

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