Volume 23, Number 6 (Biomonthly March-April 2013)                   J Urmia Univ Med Sci 2013, 23(6): 606-611 | Back to browse issues page


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Purghasem J, Alilu L, Pakzad S, Shakibi A. EVALUATION OF THE PROPHYLACTIC ANTIBIOTICS EFFECT ON THE LOW-RISK PATIENTS WHO CANDIDATE FOR ELECTIVE LAPAROSCOPIC CHOLECYSTECTOMY. J Urmia Univ Med Sci. 2013; 23 (6) :606-611
URL: http://umj.umsu.ac.ir/article-1-1567-en.html

Resident of General Surgery, , dr. purghasem@gmail.com
Abstract:   (4921 Views)

  Background & Aims : Cholecystectomy is a most known procedure in patients with gallbladder disease such as choleducolithiasis. This study aimed to study the effect of ampibactam prophylaxy (ampicillin/sulbactam) on the low-risk patients who were candidates for elective laparoscopic cholecystectomy.

  Materials & Methods: This clinical double blind work study was evaluating the elective laparoscopic cholecystectomy in 160 low-risk patients with choleducolithiasis with informed consent 2010-11. The patients were randomly divided into two groups including group A as study group that received 3gr dose of ampibactam (Jaber-ebne-Hayyan Inc) intravenously and group B as the control group that received 10cc normal saline (N/S). The information about age, sex, weight, body mass index (BMI), routine tests, hospital stay for all patients was collected. The patients during hospitalization and within 30 days after surgery were followed for incidence of infectious complications.

  Results: According to this study, 1 patient (2.1%) of the intervention group and 2 patients (5.2%) in the control group were infected with the Fisher exact test showed no significant differences between the two groups, and the incidence of infection (P=4.0). In all three cases (9.1%) had an infection in one patient (6.0%) from the intervention group and 2 patients (3.1%) of the control patients had a skin wound infection (P=5.0). (P= 8.0). The infection complications have seen in one pationet in control group after 6 and in 2 patients of study group after 5 day after cholecystectom. The mean duration of hospitalization after cholecystectomy in 80 patients in the intervention group was 2.08 ± 0.28 days versus 2.17 ± 0.4 d in the control group (P=1.0).

  Conclusion : This study results such as other studies results, don’t demonstrate the efficiency of prophylactic antibiotics in low-risk laparoscopic cholecystectomy. So preferably it's not recommended to prescribe antibiotics in low-risk laparoscopic cholecystectomy conditions.

 

   

  SOURCE: URMIA MED J 2013: 23(6): 702 ISSN: 1027-3727

 

Full-Text [PDF 323 kb]   (807 Downloads)    
Type of Study: Research | Subject: آناتومی
Received: 2013/03/4 | Accepted: 2015/01/14 | Published: 2015/01/14

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