Volume 23, Number 3 (Biomonthly Aug_Sep 2012)                   J Urmia Univ Med Sci 2012, 23(3): 283-290 | Back to browse issues page


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Ghorbanihaghjo A, Rashtchizadeh N, Hashemzadeh J, Gharighoran M. EFFECTS OF RECOMBINANT ERYTHROPOIETIN ON SERUM PARAOXONASE ACTIVITY, TOTAL ANTIOXIDANT AND LIPID PEROXIDATION LEVELS IN MALE RATS. J Urmia Univ Med Sci. 2012; 23 (3) :283-290
URL: http://umj.umsu.ac.ir/article-1-1376-en.html

Professor of Clinical Biochemistry Drug Applied Research Center, Tabriz University of Medical Sciences, , rashtchizadeh@yahoo.com
Abstract:   (12538 Views)

 

Background & Aims: Erythropoietin (EPO) is a glycoprotein hormone that secretes by renal tissue in response to hypoxia and increases red blood cell (RBC) production. Recent studies demonstrate that the EPO has protective effects against ischemia. The aim of this study was to evaluate the effect of recombinant erythropoietin (r-EPO) on serum Paraoxonase (PON) activity, total antioxidant capacity (TAC) and lipid peroxidation levels in rats.

Materials & Methods: This study included 30 male adult wistar rats divided into 3 groups randomly (n=10). Groups A (high dose r-EPO) and B (low dose r-EPO) were injected as intraperitoneal (i.p.) for one and four weeks, respectively. Control group (C) was injected in equal volume normal saline, intraperitoneally.

Results: Data analyzes showed that, in treated groups by high and low doses of r-EPO in contrast with control group, there was a significant increase (P < 0.05) in PON activity (with P = 0.026 ,P= 0.033 respectively), AE activity (with P= 0.033 ,P= 0.023 respectively) and serum TAC levels (with P =0.008, P= 0.004 respectively), statistically. A significant decrease also was observed about the MDA concentration (with P =0.002, P= 0.020 respectively) as a lipid peroxidation index.

Conclusion: Based on the results of the current study, r-EPO has the antioxidant properties and decreases lipid peroxidation. Therefore, it can be used in oxidative stress conditions.

SOURCE: URMIA MED J 2012: 23(3): 345 ISSN: 1027-3727

Full-Text [PDF 279 kb]   (1014 Downloads)    
Type of Study: Research | Subject: آناتومی
Received: 2012/08/13

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