Volume 22, Number 5 (Biomonthly Dec-Jan 2011)                   J Urmia Univ Med Sci 2011, 22(5): 474-479 | Back to browse issues page


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Valipoor F, Khadem Ansari M H, Valizadeh N, Rasmi Y. ENDOTHELIAL FUNCTION BIOMARKERS AND LIPID PROFILE IN WOMEN AND MEN WITH METABOLIC SYNDROME. J Urmia Univ Med Sci. 2011; 22 (5) :474-479
URL: http://umj.umsu.ac.ir/article-1-1119-en.html

Associate Professor , Faculty of Medicine, Urmia University of Medical Sciences, , mhansari1@umsu.ac.ir
Abstract:   (9596 Views)

  

  Background & Aims : The metabolic syndrome (MS) is a clustering of risk factors of metabolic origin that increases the risk for cardiovascular disease . Endothelial function biomarkers and lipids profile determine cardiovascular disease . Aim of this study was to investigate the effect of sex on endothelial function and lipid profile.

  Materials & M ethods: The present study involved 77 patients (59 women, 18 men) with metabolic syndrome that were defined according to Adult Treatment Panel III (three altered factors from five factors including abdominal obesity, elevated TG, low HDL-c, increased blood pressure, Fasting blood sugar (FBS) intolerance). Tests were detected by ELISA and biochemistry methods.

  Results : Body mass index (women 34.56±4.97 kg/m2 men 30.22 ± 3.01 kg/m2) waist circumference (women 110.18±10.52 cm 105.06±5.65 cm) were higher in women with metabolic syndrome (p<0.05). Total cholesterol, triglycerides FBS, HDL-c, LDL-c levels were similar in women and men with MS (p> 0.05). Endotelin-1 was significantly higher in women with MS (p< 0.05). Intercellular adhesion molecule (ICAM-1), E-selectin, NO2-, NO3- levels were similar in women and men with MS (p> 0.05). There were positive correlations between endothelial biomarkers in women with MS.

  Conclusion : Visceral obesity in women may be the major cause of metabolic syndrome. Abdominal obesity may contribute to MS through its action as an endocrine organ that produces proinflammatory cytokines . 

  Source: Urmia Med J 2011: 22(5): 483 ISSN: 1027-3727

Full-Text [PDF 212 kb]   (986 Downloads)    
Type of Study: Research | Subject: آناتومی
Received: 2011/12/5

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