Volume 22, Number 5 (Biomonthly Dec-Jan 2011)                   J Urmia Univ Med Sci 2011, 22(5): 393-398 | Back to browse issues page


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Afshari F, Niknafs B, Dezfulian A. THE ASSESSMENT OF THE ULTRASTRUCTURAL OF LUMINAL EPITHELIUM IN THE HYPERSTIMULATED MICE UTEROUS AFTER APPLICATION OF ESTROGEN AND PROGESTERONE. J Urmia Univ Med Sci. 2011; 22 (5) :393-398
URL: http://umj.umsu.ac.ir/article-1-1108-en.html

Assistant Professor Department of Histopathology and Anatomy, School of Medicine, Islamic Azad University, Tabriz Branch, Tabriz, Iran , f_afshar@iaut.ac.ir
Abstract:   (7132 Views)

  

  Background & Aims : Successful implantation of blastoctcyst requires a suitable environment of uterus. Ovarian hormones are responsible for induction of endometrial receptivity. The aim of this study was to determine the effects of different luteal support hormones on the ultrastructural changes in superovulated mice in the implantation window time.

  Materials & Methods : Adult male and female mice were used for induction of pesudopregnancy. The mice were divided into two groups: experimental and control groups. Female mice in the experimental group were superovulated and then were mated with vasectomised mice to induce psudopregnancy experimental group based on hormone injection were subdivided to five groups: sham group, estrogen, progesterone, estrogen + progesterone, and antiprogesterone + estrogen. The control group obtained without any hyperstimulation. The uterine of all groups were collected after 4.5 days of pregnancy and were prepared for the assessment of ultrastructural changes with TEM .

  Results : Our results showed that progesterone injection decreased the high of microvilli in the apical cell and increased the development of pinopods but estrogen increased the growth of microvilli while esterogen + progesterone injection increased the growth of pinopodes.

  Conclusion : The results obtained from this study showed that progesterone could not provide suitable condition of endometrium for implantation in comparison to the control group and adding estrogen to progesterone may improve endometrial condition to implant at luteal phase.  

  Source: Urmia Med J 2011: 22(5): 494 ISSN: 1027-3727

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Type of Study: Research | Subject: آناتومی
Received: 2011/12/4

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