Received: 19 Feb, 2010 Accepted: 26 May, 2010

Abstract

Background & Aims: This research was carried out for evaluation of the effects of combined aerobic exercise with vitamin C+E supplementation on plasma levels of CRP, IL-6 and F₂ – Isoprostane concentrations in obese sedentary women.

Materials & Methods:� This�study included 40 sedentary and healthy obese women that were selected randomly and were divided into four groups of 10 subjects as follows: aerobic training group (G1), 10 vitamin supplementation group (G2), combined (exercise with vitamin) group (G3), and control (G4) group. Pre and post protocol blood and urine samples were collected and the rate of CRP, IL-6 and F2 – Isoprostane concentrations were measured. Exercise programs within the range of 60-70% of your maximum heart rate were performed for 90 minutes 3 to 5 sessions a week. The subjects of vitamin group and combined group received vitamin E, and C for 29 days and the subjects of exercise and control groups took placebo during the same period. After the training course blood and urine samples were taken from the subjects.

Results:  Interaction effects of exercise and vitamin supplementation had significant impact on reduction of CRP and F2– Isoprostane means (p<0.05). Despite the significant effect exercise and supplementation on mean changes in IL-6, this interaction was not a major factor in restricting upstream inflammation signals (p>0.05)

Conclusion:�Based on research results, aerobic exercise plus vitamin C+E supplementation by reducing body fat percent and restricting upstream inflammation signals decreased cardiovascular risk factors and oxidative stress in obese sedentary women.

Address: Physiology Department, Urmia University, Urmia, Iran   Tel: (+98) 9144467079

E.mail: a.tofighi@mail.urmia.ac.ir

Source: Urmia Med J 2010: 21(3): 228 ISSN: 1027-3727